International Diabetes: At this ADA conference， your presentation is that Oxidative Stress Predicts the Progression of Peripheral and Cardiac Autonomic Nerve Dysfunction over 6-Years in Diabetic Patients. ?What is the objective and the clinical implications of this trial?
国际糖尿病：在ADA的会议上，您的演讲是“氧化应激可以预测超过6年病程的糖尿病患者外周和心脏自主神经功能异常的进展”，这一研究的目的与其临床意义是什么？

Prof. Ziegler:This is not a clinical trial， but a prospective study conducted over 6 years which shows for the first time that a marker of oxidative stress， plasma superoxide?production， is a predictor?for the development and progressionn of diabetic polyneuropathy and cardiac autonomic neuropathy. One of the most important implication is?that in future trials using antioxidants in diabetic PN， increased baseline levels of this marker could be used for on optimized patient selection
Ziegler教授：这不是一个临床研究。而是为期超过6年的前瞻性研究，它首次显示氧化应激的标记物（血浆超氧化物的产生）是糖尿病外周神经及心脏自主神经疾病的发生和发展预测因子。最重要的意义是在于将来筛选治疗糖尿病神经病变的抗氧化药物研究中，可以利用升高的氧化标记物来优化患者的选择。
 

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