内容概要：International Diabetes: Good afternoon Dr. Willi. The prevalence of glucocorticoid-induced hypoglycaemia in common diabetic and non-diabetic individuals and the relative risk of new onset diabetes individuals treated with glucocorticoids is very high， as has been reported in literature around the world. Would you please explain in brief why glucocorticoid affects glucose metabolism

International Diabetes: Good afternoon Dr. Willi. The prevalence of glucocorticoid-induced hyperglycaemia in common diabetic and non-diabetic individuals and the relative risk of new onset diabetes individuals treated with glucocorticoids is very high， as has been reported in literature around the world. Would you please explain in brief why glucocorticoid affects glucose metabolism?
国际糖尿病：下午好Willi医生。全世界的文献都报道过，在普通的糖尿病和非糖尿病个体中，糖皮质激素诱导高血糖的患病率和糖皮质激素治疗的个体中新发糖尿病的相对风险都非常高。请您简单解释一下糖皮质激素是如何影响糖代谢的？

Steven Willi: Glucocorticoids have several effects on glucose metabolism. The dominant effect seems to be a decrease in the sensitivity to insulin in skeletal muscle. What this results in is a failure of the skeletal muscle to take glucose up from the bloodstream and utilise it. The result of this is to have hyperglycaemia， particularly in the post-prandial state， so when a meal is consumed， the glucose gets into the circulation and is not absorbed by the skeletal muscle.
Willi教授: 糖皮质激素在糖代谢的多个方面起作用。最主要的作用可能是降低骨骼肌对胰岛素的敏感性，从而导致骨骼肌从血循环中摄取葡萄糖和利用葡萄糖障碍。结果就是发生高血糖特别是餐后高血糖，这是因为进餐后葡萄糖进入循环但不能被骨骼肌吸收。

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