Anastassios G. Pittas  美国塔夫茨大学医学中心

<International Diabetes>: Good afternoon Dr. Peters. In addition to its effect on bone metabolism， Vitamin D has various important physiological effects including a role in glucose homoeostasis， insulin release and response. As to your research please could you briefly describe the effect of Vitamin D on the pathogenesis of diabetes?
《国际糖尿病》：除了对骨代谢的作用之外，维生素D还有各种重要的生理效应，包括葡萄糖稳态、胰岛素的释放和反应。关于您的研究，您能简单阐述一下维生素D对糖尿病发病机制的影响吗？

Prof. Pittas: OK， there is data from animal studies and observational human studies that strongly suggest a role for Vitamin D in the pathogenesis of diabetes， but there is much less evidence from randomized trials. In terms of basic signs from animal studies， there is fairly good evidence the Vitamin D has a role in promoting beta cell health as well as improving insulin sensitivity. In terms of observational human studies， there is very good cross-sectional data showing that people with diabetes have a low level of Vitamin D， however these data do not imply causality and at the same time there are prospective observational studies that have associated low Vitamin D status with the development of type 2 diabetes， so overall the observational evidence and the animal studies are relatively robust at this point， however we do not have any randomized trials that have been specifically designed to identify a causal link.
 Pittas教授: 好的，动物实验和观察性研究的数据都强烈表明维生素D在糖尿病的发病机制中起作用，但是随机研究的证据却很少。从动物实验的基本现象来看，有很好的证据表面维生素D有促进β细胞健康和改善胰岛素敏感性的作用。就观察性研究而言，有很好的横断面数据显示糖尿病患者维生素D水平低，然而，这些数据不能提示因果关系。同时，前瞻性的观察性研究发现低维生素D状态与2型糖尿病发生相关，所以总的来说观察性研究的证据和动物实验在这一点上相对有说服力。但是我们还没有任何特别针对于发掘因果联系而设计的随机试验。

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